https://worldwidejournals.org.in/index.php/wwjournals <p>World Wide Journals was founded in Ahmedabad (India) in 2011 by Dr. Khansa Memon. World Wide Journals is known as an innovative nursing, psychology, counseling, public health, social work, gerontology, and rehabilitation publisher. Dr. S. Menon is the CEO of World Wide Journals PVT LTD, which is privately held by Dr. Khansa Memon.</p> <p>The primary goal of this open access online journal is to publish original research papers in all the subjects. It intends to publish 12 issues a year and is currently accepting manuscripts. World Wide Journals will also keep all the traditional features of paper print such as a unique cover page for every issue, continuous volume, issue, and page numbers. All manuscripts including reviews will be subjected to peer review and published online every 1st Day of the Month after acceptance.</p> <p>The Journal is registered with National Institute of Science Communication and Information Resources, New Delhi having ISSN registration number 2249-555X.</p> World Wide Journals en-US World Wide Journals 2249-555X https://worldwidejournals.org.in/index.php/wwjournals/article/view/85 <p>Sickle cell anemia is an inherited disorder caused by a point mutation in gene that encodes the β-globin chain of hemoglobin. The mutation results in replacement of glutamate by valine. The mutant hemoglobin (HbS) polymerizes red blood cells &amp; cause blockage, resulting in acute, severe pain called a sickle cell crisis. Sickle cell diseases (SCDs) is an emerging public health challenge, not only in India but also globally. In India, SCD is distributed geographically in the central and western regions. Here we are presenting a rare case of Sickle Cell Trait with Severe Anemia with Megaloblastic changes in a middle aged man in Tripura. A Male patient in his forties came to the OPD with severe lethargy &amp; generalised weakness. Patient had Hypoalbuminemia, Anemia with Marked Anisopoikilocytosis. Bone marrow showed Megaloblastoid changes. After evaluation of<br>HPLC Chromatogram of Hemoglobin Electrophoresis with a Sickle Window of 15.7 %, HbA2 2.6%, HbF &lt;0.8%, HbA0 71.6% was diagnosed as Sickle Cell Trait by the Authors. Although Sickle Cell Trait being the benign form of the disease, here it presented with severe Anemia. Hypoalbuminemia also supports the nding of Pedal Edema. Treatment provider we should always look for hematological status of the patient &amp; encourage the patient for treatment of Anemia.</p> Dr. Supratim Acharjee Dr. Supratim Acharjee Prof. (Dr.) Chinmoy Biswas Prof. (Dr.) Chinmoy Biswas Dr. Chayanika Biswas Dr. Chayanika Biswas Copyright (c) 2024 World Wide Journals 2024-09-25 2024-09-25 13 02