World Wide Journals

INVESTIGATION OF AUTONOMIC FUNCTIONS IN ADULTS AFTER COVID-19 (SARS-COV-2) INFECTION USING SYMPATHETIC SKIN RESPONSE AND R-R INTERVAL VARIATION

2025-03-13T05:17:48+00:00

The SARS-CoV-2 (COVID-19) pandemic has inicted unparalleled morbidity and mortality on a global
scale. Over time, as our understanding of the disease has grown, we have come to recognize the
existence of long-term effects that transcend the initial acute phase. Sympathetic skin response (SSR) and R-R interval
variability (RRIV) have been employed as methods to evaluate the function of the autonomic nervous system (ANS).
Consequently, we have undertaken this study with the objective of investigating ANS function in patients who have recovered
from COVID-19. Methods We enrolled a total of 51 individuals who had recovered from COVID-19 and 49 healthy individuals for
this study. The assessment of autonomic function involved the evaluation of RRIV and SSR. Results In the case group
comprising 51 individuals, 23 (45.1%) were male, and 28 (54.9%) were female. The age range of these patients varied from 21 to
86 years. Within the control group, consisting of 49 individuals, 24 (49%) were male, and 25 (51%) were female. Our ndings
revealed a notable correlation between COVID-19 infection and abnormal SSR parameters. However, when we examined RRIV,
we did not nd a statistically signicant difference in RRIV parameters between the patient and control groups. Conclusions
Our study suggests that abnormal SSR parameters could serve as a valuable indicator of ANS involvement in patients with
COVID-19 infection. We did not nd a signicant difference in RRIV parameters between the case and control groups.

RELATIVE ENERGY DEFICIENCY IN SPORT (RED-S): ADULT FEMALE CLUBLEVEL SWIMMERS

2025-03-15T08:39:29+00:00

Background: Relative Energy Deciency in Sport (RED-S) occurs when there is an imbalance between energy intake and expenditure, impacting
athletes' health and performance. The Low Energy Availability in Females Questionnaire (LEAF-Q) is a widely used validated screening tool for
RED-S in athletes, assessing early symptoms of energy deciency in women with 90% specicity and 78% sensitivity, making it easy and
inexpensive to implement. Aim And Objectives: The study aims to evaluate the prevalence of RED-S among adult female club-level swimmers
using the LEAF-Q. It aims to identify the proportion of swimmers at risk, assess symptoms, and analyse the relationship between body composition
and RED-S risk. The study also aims to identify differences in RED-S risk among different age groups. Methods: A survey-based cross-sectional
study was conducted on 118 adult female club-level swimmers from Mumbai. Participants completed the LEAF-Q, with additional data collected
on age, body composition (BMI), and related symptoms. Results: More than half of the swimmers (58.47%) are at risk of RED-S. A total of 69
swimmers are classied as at risk of RED-S, with 97.46% reporting symptoms linked to injury risk. Menstrual irregularities affect 43.22%, while
38.14% report gastrointestinal issues. A negative correlation is observed between BMI and LEAF-Q scores, indicating a higher risk with normal
body composition. Conclusion: The study concludes that a signicant proportion of adult female club-level swimmers are at risk of RED-S these
ndings emphasize the need for increased awareness and preventive strategies to address RED-S in female swimmers.

A RARE CASE OF SICKLE CELL TRAIT WITH SEVERE ANEMIA WITH MEGALOBLASTOID CHANGES IN TRIPURA : CASE REPORT

2024-09-25T14:03:17+00:00

Sickle cell anemia is an inherited disorder caused by a point mutation in gene that encodes the β-globin chain of hemoglobin. The mutation results in replacement of glutamate by valine. The mutant hemoglobin (HbS) polymerizes red blood cells & cause blockage, resulting in acute, severe pain called a sickle cell crisis. Sickle cell diseases (SCDs) is an emerging public health challenge, not only in India but also globally. In India, SCD is distributed geographically in the central and western regions. Here we are presenting a rare case of Sickle Cell Trait with Severe Anemia with Megaloblastic changes in a middle aged man in Tripura. A Male patient in his forties came to the OPD with severe lethargy & generalised weakness. Patient had Hypoalbuminemia, Anemia with Marked Anisopoikilocytosis. Bone marrow showed Megaloblastoid changes. After evaluation of
HPLC Chromatogram of Hemoglobin Electrophoresis with a Sickle Window of 15.7 %, HbA2 2.6%, HbF <0.8%, HbA0 71.6% was diagnosed as Sickle Cell Trait by the Authors. Although Sickle Cell Trait being the benign form of the disease, here it presented with severe Anemia. Hypoalbuminemia also supports the nding of Pedal Edema. Treatment provider we should always look for hematological status of the patient & encourage the patient for treatment of Anemia.